Da Vinci's journals feature over 6,000 pages of notes and drawings and chronicle the life of the world's most renowned inventor, philosopher, painter and genius.
The show will use stunning visual effects and 3D technology to recreate the polymath's mindscape and ideas.
"Leonardo's journals are an extraordinary body of work, highlighting Da Vinci's position at the vanguard of ideas, thought and design. It's wholly fitting therefore, that his works are being brought to life in such a creative way with the use of Sky's cutting edge 3D technology," said James Hunt, channel director of Sky Arts.
Inside the Mind of Leonardo airs on Sunday, March 24 at 9pm on Sky Arts 2 and Sky 3D.